Introduction: The Hypoxic-Hyperoxic Axis of Human Longevity
Hyperbaric Oxygen Therapy (HBOT) involves breathing 100% (pure) oxygen in a special space called a hyperbaric chamber. The air pressure inside is raised to a higher level than normal air pressure. The increased air pressure in the chamber helps the lungs collect more oxygen. One of the most recent and well-known people in this field is Dr. Shai Efrati (cofounder of Aviv Clinics), developing oxygen therapy programs since 2017 and offering hyperbaric sessions in their high-end clinics in Israel, Florida, and Dubai.
Aviv Scientific was the subject of substantial media coverage surrounding the results of a clinical study in late 2020, which purported to demonstrate ‘age-reversing’ effects resulting from hyperbaric oxygen therapy. The study's authors showed telomere elongation in circulating immune cells and a reduction in the number of circulating immunosenescent cells, which indicates age reduction.
However, the media coverage of the study has been accused of overhyping it by many experts in ageing research. A closer look at the data in context reveals that, although hyperbaric oxygen therapy did show an increase of ~20% in average telomere length in certain immune cells, the T cells being examined have highly dynamic telomeres. Depending on their situation, they can fluctuate considerably, something that can happen anyway as a result of regular exercise. In other words, the study is less revelatory than it first appears. On the other hand, during a discussion on this study in an April 2021 webinar hosted by Aging Analytics Agency in which Dmitry Kaminsky took part, alongside gerontologist and integrative medicine physician Dr. Arkadi Prokopov, it quickly became evident that much of the criticism surrounding the study is the result of measuring just a few biomarkers (i.e., telomere length and the number of circulating immunosenescent cells). It became clear that a more diverse and comprehensive set of Biomarkers of Longevity could have produced a more revelatory and evident study.
Individualized Normobaric Intermittent Hypoxic-Hyperoxic Training (IHHT) Based on Mitochondria Optimization Protocol (MITOPRO) — Cutting-edge Method for Practical Human Longevity
It is generally accepted that Mitochondria dysfunction in multiple cell types is a core factor of ageing. In scientific literature it is described as a Hallmark of Ageing, nevertheless, it is proven that mitochondria function strongly affects other hallmarks. At the current moment, more than one hundred individual programs are studying the central role of mitochondria in ageing and targeting mitochondrial dysfunction. MITOPRO (unique therapeutic and regenerative method developed by Dr. Arkadi Prokopov, which helps to slow down ageing, prevent aging-related diseases, and accelerate the restoration of health in chronic diseases. More about this method, you can read on his website.) unlike other protocols (Therapeutic Mitochondrial uncoupling, Genetic Modification, Mitochondrial Transfusion, and other), is based on well-studied principle of regeneration activation.
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Mitochondria Rejuvenation can be uniquely achieved by natural stimuli using MITOPRO approach. Unlike pharmacological therapies and cell manipulative or gene-editing methods, MITOPRO is stimulating cells for reparation, regeneration and as s result rejuvenation by physically promoting natural environmental signals which can be read by any cell. Signalling pathways involved in that approach have been developing for millions of years and are basic for human cells. You can read more about mitochondria's role in Longevity in the analytical case study ‘Mitochondria in Longevity and Space Medicine’ produced by Aging Analytics Agency.​​
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​In the book ‘Biomarkers of Human Longevity’ Dmitry Kaminskiy describes, ‘For several months over the course of 2020-2021, I have been undergoing briefing sessions using advanced equipment using a specific and specialized method known as Intermittent Hypoxic-Hyperoxic Intensive Training (IHHIT), and I have seen not only positive changes in my own Longevity Biomarkers, but a significant increase in my physical and cognitive performance and endurance.
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Note: The figure above depicts my personal maximum result on Intermittent Hypoxic-Hyperoxic Intensive Training. During a 70 minutes session, I achieved an HTI level (Hypoxia Training Index) of 819, which may be considered as one of the highest results in the world. Approximately 50% of the training session time was in hibernation mode, whereas during approximately 20 minutes my blood saturation went down to the level of 50-60%. While my highest result to date was an HTI of 819, typically I am doing intensive trainings in the range of 300-500 HTI, which is a standard level for professional alpinists, high-performance athletes and marathon runners, and in a more relaxed daily mode I am doing trainings in the range of 170-250 HTI.’
While the IHHT method utilizes a specific protocol (which enables it to work more safely and effectively than other protocols within this category of intervention, for example, such as hyperbaric chambers and HBOT method), the broad domain of therapies encompassed by intermittent hypoxic and hyperoxic stress (and more generally by intermittent breathing techniques) has been used in humans for many decades, creating a large volume of evidence regarding its safety and efficacy. It is well documented in multiple scientific papers. And it is, indeed, uniquely and coincidentally a domain of research that accumulated a large amount of evidence in humans before achieving positive results in model organisms.
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Before formal clinical trials and studies demonstrating the safety and therapeutic value in humans of intermittent hypoxic/hyperoxic stress for a number of specific diseases and conditions (including cognitive impairment and neurodegenerative disease, prediabetes, heart disease, coronary artery disease and cardiorespiratory conditions, impaired mobility), this broad domain of intermittent breathing techniques received many decades-worth of studies in human patients focused on its effects on intensive athletic performance, high-altitude (alpine) training (both in young and older individuals) and as a core, standard and systematically-applied technique for training cosmonauts for space flight within the scope of USSR-era space medicine, for improving the performance of deep-sea divers, and as a preventive strategy for certain occupational hazards in situations of exposure to extreme environmental hazards (such as clean-up groups working in Chernobyl).
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Today, the broad domain of intermittent breathing techniques enhanced by specialized equipment (which encompass IHHT, HBOT and other variations and specific protocols) are used regularly by high-performance athletes (Olympic champions, long-distance marathon runners, deep divers, alpinists, etc.), by high-profile businessmen and other intensive-occupation professionals to enhance cognitive performance and endurance, and also as a recovery technique in post-Covid-19 pathologies and other very complex diseases like Lyme Disease and Leigh Syndrome.
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Methods aimed at mitochondrial rejuvenation are already contributing to the normalization of organism functioning. At the time, evidence of reverse ageing of organisms using these technologies is only a matter of more profound research. Researchers have already acquired some proof of signs of reverse ageing, but for full-scale admission, a full-scale study with a large pool of ageing biomarkers has yet to take place.
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In Dmitry Kaminskiy’s 2021 book Biomarkers of Human Longevity, I made very specific reference to IHHT-based ptorocols as the real game changer for Practical Longevity: ‘The specific protocol that I am using personally (IHHT) was developed by Dr. Arkadi Prokopov, an integrative medicine physician and gerontologist with over 30 years experience in the effects of hypoxia and hyperoxia on Human Longevity, who developed his unique and specialized IHHT protocol through his experience working as part of a government-led Space Medicine program, and the equipment I am using comes directly from Dr. Prokopov’s company, Athletic HighTech S.L. Arkadi himself uses this technique, and his personal results are also quite compelling – being 72, doing regular athletics and endurance training, and possessing the strength and performance of absolutely healthy people in their 30s-40s, which I have witnessed first-hand during my consultations with him’.
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During a discussion in June 2021 at the conference ‘Practical Applications of Mitochondria Research for Human Longevity and Space Medicine’ hosted by Aging Analytics Agency, Dmitry Kaminskiy said, “considering both my own personal results and the large scope and depth of human studies published on this technique, I have full confidence that this broad category of intervention, including hyperbaric chambers and intermittent breathing (hypoxic, hyperoxic) methods, are not just working safely and effectively enough to provide health and performance benefits, but are also working to confer some level of rejuvenation and reversal of biological ageing in humans.”
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Practical Applications for People with Extraordinary Cognitive Requirements
H5I2T (Hypoxic, Hyperoxic, Hypercapnia, Hypocapnia High-Intensity Interval Training) has emerged as a promising protocol for enhancing neuro-performance and cognitive function, particularly for advanced professionals who face extraordinary cognitive demands. By integrating controlled breathing exercises and stress modulation, H5I2T offers a multifaceted approach to overcoming procrastination, boosting motivation, and optimizing cognitive performance.
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Overcoming the Procrastination Problem and Motivation Deficit: Procrastination and a lack of motivation are common challenges faced by professionals in high-pressure environments. H5I2T addresses these issues by promoting mental resilience and focus through controlled stress exposure. The intermittent hypoxic and hyperoxic intervals of H5I2T stimulate the release of neurotransmitters like dopamine and serotonin, which play key roles in motivation and reward processing. By engaging in regular H5I2T sessions, individuals can cultivate a proactive mindset, enhance their ability to prioritize tasks, and overcome procrastination barriers.
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Increasing Neuronal Cell Mitochondrial Mass for High-Performance Professions: Mitochondria are the powerhouse of the cell, responsible for generating energy and maintaining cellular function. In high-performance professions, optimal mitochondrial function is essential for sustaining cognitive performance and mental clarity. H5I2T promotes mitochondrial biogenesis and increases neuronal cell mitochondrial mass through its combination of hypoxic and hyperoxic intervals. By exposing the brain to fluctuating oxygen levels, H5I2T stimulates mitochondrial adaptation and enhances cellular energy production, leading to improved cognitive function and mental acuity.
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Special Techniques for Financiers, Hedge-Fund Managers, and Decision Makers: Professionals in finance, hedge-fund management, and decision-making roles often face intense cognitive demands and require peak mental performance. H5I2T offers specialized techniques tailored to the needs of these individuals, including strategic breathing exercises and stress modulation protocols.
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By incorporating hypoxic and hyperoxic intervals into their daily routine, financiers and decision-makers can optimize brain oxygenation, enhance cognitive flexibility, and improve decision-making accuracy. Additionally, H5I2T fosters neuroplasticity and resilience, enabling professionals to adapt to changing market conditions and maintain a competitive edge in their field.
In summary, H5I2T serves as a comprehensive protocol for enhancing neuro-performance and cognitive function in advanced professionals. By addressing procrastination, optimizing mitochondrial function, and offering specialized techniques for high-performance professions, H5I2T empowers individuals to meet extraordinary cognitive demands and achieve peak mental performance in their respective fields.
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